Featured Publications

Nature Genetics 2025 cover
ERG-driven prostate cancer initiation is cell context dependent and requires KMT2A and DOT1L
Feng W*,#, Ladewig E*, Lange M, Salsabeel N, Zhao H, … Sawyers CL#
Nat Genet (2025)

Want to rewrite the oncogenic flavor? Just change that cup of tea!

PNAS 2021 cover
Rapid interrogation of cancer cell of origin through CRISPR editing
Feng W*, Cao Z*, Lim PX, Zhao H, … Sawyers CL
Proc Natl Acad Sci (2021)

One step to build complex, immunocompetent cancer models!

Nature Communications 2017 cover
BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination
Feng W, Jasin M
Nat Commun (2017)

A wound in S phase, a reckoning much later.

Research Articles

(*: co-first author; #: co-corresponding author)

  • Feng W*,#, Ladewig E*, Lange M, Salsabeel N, Zhao H, Lee YS, Gopalan A, Luo H, Kang W, Fan N, Rosiek E, de Stanchina E, Chen Y, Carver BS, Leslie CS, Sawyers CL#. ERG-driven prostate cancer initiation is cell context dependent and requires KMT2A and DOT1L. Nat Genet (2025)
  • Lim PX, Zaman M, Feng W, Jasin M. BRCA2 promotes genomic integrity and therapy resistance primarily through its role in homology-directed repair. Mol Cell (2024)
  • Celada SI, Li G, Celada LJ, Lu W, Kanagasabai T, Feng W, Cao Z, Salsabeel N, Mao N, Brown LK, Mark ZA, Izban MG, Ballard BR, Zhou X, Adunyah SE, Matusik RJ, Wang X, Chen Z. Lysosome-dependent FOXA1 ubiquitination contributes to luminal lineage of advanced prostate cancer. Mol Oncol (2023)
  • Wasmuth EV, Broeck AV, LaClair JR, Hoover EA, Lawrence KE, Paknejad N, Pappas K, Matthies D, Wang B, Feng W, Watson PA, Zinder JC, Karthaus WR, de la Cruz MJ, Hite RK, Manova-Todorova K, Yu Z, Weintraub ST, Klinge S, Sawyers CL. Allosteric interactions prime androgen receptor dimerization and activation. Mol Cell (2022)
  • Feng W*, Cao Z*, Lim PX, Zhao H, Luo H, Mao N, Lee YS, Rivera AA, Choi D, Wu C, Han T, Romero R, de Stanchina E, Carver BS, Wang Q, Jasin M, Sawyers CL. Rapid interrogation of cancer cell of origin through CRISPR editing. Proc Natl Acad Sci (2021)
  • Feng W, Jasin M. 53BP1 nuclear body-marked replication stress in a human mammary cell model of BRCA2 deficiency. BioRxiv (2018)
  • Feng W, Jasin M. BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination. Nat Commun (2017)
  • Vanoli F, Tomishima M, Feng W, Lamribet K, Babin L, Brunet E, Jasin M. CRISPR-Cas9-guided oncogenic chromosomal translocations with conditional fusion protein expression in human mesenchymal cells. Proc Natl Acad Sci (2017)

Reviews

  • Feng W, Jasin M. Homologous Recombination and Replication Fork Protection: BRCA2 and More! Cold Spring Harb Symp Quant Biol (2018)
  • Chen CC*, Feng W*, Lim PX, Kass EM, Jasin M. Homology-Directed Repair and the Role of BRCA1, BRCA2, and Related Proteins in Genome Integrity and Cancer Annu. Rev. Cancer Biol (2018)
  • Prakash R*, Zhang Y*, Feng W*, Jasin M. Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins. Cold Spring Harb Perspect Biol (2015)